Κλινική ανάπτυξη βασισμένη σε επιστημονική εμπειρία
και εξελιγμένες μεθοδολογίες

Κλινικές δοκιμές

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The Bulgarian Cardiac Institute, in collaboration with the pharmacological industry, takes an active part in the clinical development of medicine through healthcare data evaluation, innovative healthcare technologies, improved methodology and clinical experience.

All clinical trials are performed according to the European and Bulgarian legislation requirements and the good clinical practice.

In November 2022, Heart and Brain successfully passed an inspection conducted by the U.S. Food and Drug Administration (FDA) with following assessment: ,,no significant observations, with recognition of the openness of the clinical centre”.

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Area Research Centre Principal Investigator Condition or disease Completed Ongoing
Cardiology Cardiology Hospital Pleven Dr Valentin Hristov Type2 Diabetes; Dyslipidemia X
Cardiology Cardiology Hospital Pleven Dr Valentin Hristov Cardiovascular Disease X
Cardiology Cardiology Hospital Pleven Dr Valentin Hristov Myocardial Infarction X
Cardiology Cardiology Hospital Pleven Dr Valentin Hristov Atrial Fibrillation X
Cardiology Cardiology Hospital Varna Prof. Nikolay Penkov Acute Coronary Syndrome X
Cardiology Cardiology Hospital Varna Prof. Nikolay Penkov High cholesterol X
Cardiology Heart and Brain Pleven Prof. Iana Simova COVID-19 X
Cardiology Heart and Brain Pleven Prof. Iana Simova COVID-19 X
Cardiology Heart and Brain Pleven Prof. Iana Simova COVID-19 X
Cardiology Heart and Brain Pleven Prof. Iana Simova COVID-19 X
Cardiology Heart and Brain Pleven Prof. Iana Simova Hypertension X
Cardiology Heart and Brain Pleven Prof. Iana Simova Hypertension X
Cardiology Heart and Brain Pleven Prof. Iana Simova Atherosclerotic Cardiovascular Disease X
Cardiology Heart and Brain Pleven Prof. Iana Simova Heart Failure With Preserved Ejection Fraction X
Cardiology Heart and Brain Pleven Prof. Iana Simova Atherosclerotic Cardiovascular Disease X
Cardiology Heart and Brain Pleven Prof. Iana Simova Cardiovascular Risk, Chronic Kidney Disease, Inflammation X
Cardiology Heart and Brain Pleven Prof. Iana Simova Myocardial Infarction X
Cardiology Heart and Brain Pleven Prof. Iana Simova Cardiovascular Disease X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Focal seizures in adult subjects with drug-resistant focal epilepsy X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Focal seizures in adult subjects with drug-resistant focal epilepsy X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Relapsing-remitting form of multiple sclerosis X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Relapsing forms of multiple sclerosis X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Migraine X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Parkinson’s disease X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov COVID-19 X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Parkinson’s disease X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Progressive multiple sclerosis X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Relapsing-remitting form of multiple sclerosis X
Neurology Heart and Brain Pleven Prof. Plamen Bozhinov Stereotyped, prolonged seizures X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Squamous Cell Non Small Cell Lung Cancer; Prostate Cancer; Metastatic Cutaneous Melanoma; Colorectal Cancer; Advanced Cancer; Solid Tumor, Adult X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Cutaneous Squamous Cell; Carcinoma Advanced Cutaneous Squamous Cell Carcinoma; Metastatic Cutaneous Squamous Cell Carcinoma X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova ER-Positive HER2-Negative Breast Cancer X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Breast Neoplasms; Breast Cancer; HER2-positive Early Breast Cancer X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Locally Advanced or Metastatic Unresectable Urothelial Cancer X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Carcinoma, Non-Small-Cell Lung X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Hormone-Sensitive Prostate Cancer X
Oncology Heart and Brain Pleven Assoc. Prof. Natalia Chilingirova Non-Small Cell Lung Cancer X
Cardiology Heart and Brain Burgas Assoc. Prof. Lilyana Mircheva Prevention of Stroke or Systemic Embolism; Atrial Fibrillation X
Neurology (Medical Imaging Department ) Heart and Brain Burgas Prof. Ivan Dimitrov (with Ass. Prof. Lachezar Manchev) Multiple Sclerosis X

Status: March 2023; the list is not exhaustive.

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